Table of Contents
Cellular Basis of Synaptic Plasticity
Cellular (esp. structural) Basis of
Learning and Memory
History
1949 Hebb's Postulate Revives "Structural Basis of Learning"
Hippocampal CA1 Pyramidal Cell
Excitatory Synapses on Dendritic Spines
SYNAPSE WEB - 3D series to study spines K24
Diversity in Hippocampal Spine Shapes
Hippocampal Spine Structure
CA1 PSD Areal Dimensions:
0.01 - 0.54 ?m2
Presynaptic Vesicles
Dimensions of Pre and Postsynaptic Elements are Proportional to one another
ENRICHED ENVIRONMENTS!!
EC reared rats have more dendrites
Enhanced Spatial Learning Water Maze
Enrichment and training over days = more spines
MENTAL RETARDATION
Spines in Normal vs. Retarded Human
Spine Loss with Seizures
Spine Loss with Seizures
Spine Loss with Seizures
Long-term Potentiation (LTP)
Hippocampal Synapses that Show LTP
CA3 -> CA1 LTP
Two different synapses to same cell can show different types of LTP
Early Phase of LTP due to increased release at existing synapses
Late phase LTP results in more peaks, suggesting new synapses brought on line
Synaptic Changes that could mediate LTP and underlie Learning and Memory
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