Table of Contents
Cellular Basis of Synaptic Plasticity
Cellular Basis of Synaptic Plasticity
What are some sites where structural changes in synapses might influence LTP?
LTP in Immature Hippocampal Neurons
Hippocampal Dendritic Filopodia at PN6
Spinogenesis during Development
Role of activity in filopodial outgrowth
Role of synaptically released glutamate in dendritic spine formation 1
Role of synaptically released glutamate in dendritic spine formation 2
Subset of synapses change connectivity with LTP in organotypic slices 1
Subset of synapses change connectivity with LTP in organotypic slices 2
Subset of synapses change connectivity with LTP in organotypic slices 3
Blockade of LTP prevents morphological correlates
Caveats
Summary
Might LTP preserve newly formed synapses?
Slice Physiology and DiI Conditions
Scoring Strategies
Mature Hippocampal Dendrite Tips
Mature Dendrites Become More Spiny Possibly to Compensate for Lost Synaptic Activity
Learning and Memory
Aplysia - Model System
Long-term Sensitization - Aplysia
Long-term Habituation - Aplysia Behavior
Long Term Habituation - Aplysia
Aplysia - Axonal Arbors increase after 10 days of Sensitization
Aplysia - Axonal Varicosities
Aplysia - Axonal Varicosities
Aplysia - Synapse Anatomy
Aplysia - Synapse Plasticity
Aplysia Sensory to motor neuron synapses in culture
Aplysia - Step 1 of synaptogenesis after serotonin
Aplysia - 5-HT induced ApCAM internalization and degradation
Aplysia - Internalization and degradation of ApCAM
Aplysia - Model for Role of membrane recycling in Synaptic plasticity with Long Term Sensitization
Aplysia Summary
ENRICHED ENVIRONMENTS!!
EC reared rats have more dendrites
Enriched spatial rearing
Enrichment and training over days = more spines
Role of NMDA receptor in learning
Non-spatial memory task impairment in CA1-NMDA KO mice
Enrichment improves learning on BOTH the controls and NMDA-KO mice
Enrichment causes more spines and synapses (macular only) in both Naïve and KO mice
Summary - Enrichment/Learning
MENTAL RETARDATION
MENTAL RETARDATION
Spine Loss with Seizures
Spine Loss with Seizures
Spine Loss with Seizures
Conclusions
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