Table of Contents
Synaptic activity dependent signal transduction leading to neuronal adaptive responses that are needed for information storage in the brain.
Calcium and signal transduction
Modes of Calcium Entry
Modes of Calcium Entry
Calcium Regulated Genes
Calcium mediated
transcription-independent responses
Calcium mediated
transcription-dependent responses
Transcription of c-fos
Calcium Regulation of Gene Transcription (esp c-fos)
CREB domain structure
CREB domain structure
Multiple Domains of CREB contributing to transcriptional activation
Calcium Regulated CREB Kinases
Neuron Specific, calcium-regulated IEGs -
BDNF - calcium regulated IEG largely restricted to neuron
Why 4 distinct BDNF promoters
Model how products of calcium-regulated genes might affect synaptic function
How to get synaptic specificity
in this system?
Calcium from different sources triggers different signaling pathways to gene expression.
Calcium influx domains - Hippocampal Pyramidal Cell
Calcium influx at Purkinje cells
Targeted Gene expression
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