Table of Contents
Postsynaptic Dendritic Spine Structure and Composition
Hippocampal CA1 Pyramidal Cell
Dendritic Spines
Diversity in Hippocampal Spine Shapes
Hippocampal Spine Diversity
Branched CA1 Spines
Hippocampal Spine Structure
CA1 PSD Areal Dimensions:
0.01 - 0.54 ?m2
Similarity among Purkinje Spine shapes - lollipops
Range in Cerebellar Spine diversity
Cerebellar branched spines
Hippocampal CA1 vs. Cerebellum
Correlation between PSD area and other features of the synapse:
Functions That Have Been Ascribed To Spines
Functions That Have Been Ascribed to Spines
Functions of Dendritic Spines
Do Spines Modulate Charge Transfer from the Synapse?
Percent Reduction in charge transfer for measured spine necks
Percent Reduction in charge transfer when synaptic input is greater
Synapse Associativity
Voltage Amplification (V2)
Presynaptic Axon doesn't mandate spine shape
Or even that there be a spine
However, spines allow more synapses per brain volume
And provide enhanced connectivity between neurons
Synapse Specificity Through Molecular Compartmentalization
Synapse Specificity through Local Protein Synthesis
~50% of all Ca1 Spines have SER
Cerebellar Spine and SER compartments
Polyribosomes in spines
If time also see website
Endocytosis in Spines
Spine Summary
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