Modification of Brain Circuits as a Result of Experience

4/11/01


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Table of Contents

Modification of Brain Circuits as a Result of Experience

Process of Establishing Initial Brain Organization (Chapter 23, Dr. Li)

Role of Experience in the next stage of Neural Development

Experience Switching on Innate Behaviors

Plasticity in the Developing Brain

Critical Periods

Critical Periods

Critical Period for Language Acquisition (before 7 years)

Deaf Children with Signing Deaf Parents

Possible Roles of Experience in Language Acquisition

Critical Periods and Vision

How studied?

Anatomical Projections

Axonal Transport of Radioactively Labeled amino acid such as proline

Normal Ocular Dominance Columns in Visual Cortex in Macque Monkey

Single Unit Responses in Normal Kitten Visual Cortex

Monocular deprivation in kitten

What about other parts of the Visual Pathway?

Longer monocular deprivation in the adult cat

Brief Monocular Deprivation During the Critical Period at 3-4 weeks postnatal

Ocular Dominance Columns have equal widths at Birth (Macaque Monkey)

Non-deprived eye captures more of Visual Cortex

Axonal branching expansion as basis of ocular dominance stripe widening

Activity dependent Competition

Neurons that Fire together Wire Together and their connections are preserved

Strabismis = uncorrelated activity

Other Brain Regions have similar developmental Critical periods

Summary

Author: Kristen Harris